The Mouse Nervous System

The Mouse Nervous System

Language: English

Pages: 814

ISBN: 0123694973

Format: PDF / Kindle (mobi) / ePub


The Mouse Nervous System provides a comprehensive account of the central nervous system of the mouse. The book is aimed at molecular biologists who need a book that introduces them to the anatomy of the mouse brain and spinal cord, but also takes them into the relevant details of development and organization of the area they have chosen to study. The Mouse Nervous System offers a wealth of new information for experienced anatomists who work on mice. The book serves as a valuable resource for researchers and graduate students in neuroscience.

  • Systematic consideration of the anatomy and connections of all regions of the brain and spinal cord by the authors of the most cited rodent brain atlases
  • A major section (12 chapters) on functional systems related to motor control, sensation, and behavioral and emotional states
  • A detailed analysis of gene expression during development of the forebrain by Luis Puelles, the leading researcher in this area
  • Full coverage of the role of gene expression during development and the new field of genetic neuroanatomy using site-specific recombinases
  • Examples of the use of mouse models in the study of neurological illness

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projection to the hippocampal formation. Hippocampus 2003;13:133–149. van Strien NM, Cappaert NL, Witter MP. The anatomy of memory: an interactive overview of the parahippocampal-hippocampal network. Nature reviews. Neuroscience 2009;10:272–82. Vertes RP, Hoover WB, Do Valle AC, Sherman A, Rodriguez JJ. Efferent projections of reuniens and rhomboid nuclei of the thalamus in the rat. Journal of comparative neurology 2006;499:768–796. Vuksic M, Del Turco D, Bas Orth C et al. 3D-reconstruction and

two loxP sites (or frt sites), thus deleting the “STOP” cassette, resulting in expression of the reporter in all cells that express Cre, and, importantly, in all their descendents. Some considerations are that there is a minimum expression level of the Cre (or Flp) protein required to induce recombination, and the level depends on the particular reporter allele used. Thus, not all cells that express Cre or Flp will acquire expression of the marker gene. However, once expressed, the reporter will

that constrains the way in which neurons can connect” (Douglas & Martin, 2004, p.421) maximizing the connective potential of cortical circuits and scaling efficiently with increasing size. In turn, this seems to underpin the extraordinary adaptability and usefulness of the mammalian cerebral cortex (Kaas, 2009). The layered structure is fundamental to the anatomy and function of the neocortex. The neurons of each layer are born concurrently and as a result their gene expression and subsequent

frequency shifts in 85 membrane potential impose a bistable pattern of excitability thresholds on some principal neurons, referred to as up and down states (Crochet & Petersen, 2006; Steriade, 2000; Wilson, 2008). These may be triggered by thalamic afferents, and in turn they influence cortical responses to thalamic activity (MacLean et al., 2005). Although rigorous demonstrations of neuronal connectivity have previously required laborious cell filling and electron microscopy (Nieuwenhuys,

sections into a three dimensional model is technically challenging, resulting in irregular region borders which have been regularized for the purpose of this illustration. It indicates the possibility for dimensionally accurate renderings based on histological data, easing translation between cross-sectional anatomy and surface-based or tangential data (e.g. Wang & Burkhalter, 2007). Specific Cortical Areas The organization and function of individual cortical regions is discussed elsewhere in

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