Protein Oxidation and Aging

Protein Oxidation and Aging

Tilman Grune

Language: English

Pages: 524

ISBN: 0470878282

Format: PDF / Kindle (mobi) / ePub


Reviews our current understanding of the role of protein oxidation in aging and age-related diseases

Protein oxidation is at the core of the aging process. Setting forth a variety of new methods and approaches, this book helps researchers conveniently by exploring the aging process and developing more effective therapies to prevent or treat age-related diseases. There have been many studies dedicated to the relationship between protein oxidation and age-related pathology; now it is possible for researchers and readers to learn new techniques as utilizing protein oxidation products as biomarkers for aging.

Protein Oxidation and Aging begins with a description of the tremendous variety of protein oxidation products. Furthermore, it covers:

  • Major aspects of the protein oxidation process
  • Cellular mechanisms for managing oxidized proteins
  • Role of protein oxidation in aging
  • Influence of genetic and environmental factors on protein oxidation
  • Measuring protein oxidation in the aging process
  • Protein oxidation in age-related diseases

References at the end of each chapter serve as a gateway to the growing body of original research studies and reviews in the field.

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dismutase 1 mutant. Proc. Natl. Acad. Sci. U.S.A. 94: 7606–7611. 679. Leeuwenburgh, C., Hardy, M. M., Hazen, S. L., Wagner, P., Oh-ishi, S., Steinbrecher, U. P. & Heinecke, J. W. (1997) Reactive nitrogen intermediates promote low density lipoprotein oxidation in human atherosclerotic intima. J. Biol. Chem. 272: 1433–1436. 680. Souza, J. M., Choi, I., Chen, Q., Weisse, M., Daikhin, E., Yudkoff, M., Obin, M., Ara, J., Horwitz, J. & Ischiropoulos, H. (2000) Proteolytic degradation of tyrosine

molecular targets for •NO (151). •NO binding to guanylate cyclase results in enzyme activation and subsequent conversion of guanosine monophosphate (GMP) to cGMP. The ultimate consequence of cGMP synthesis is relaxation of vascular smooth muscle. Addition of •NO to other heme groups has been reported, and may significantly influence the redox environment of the cell. For instance, Kanner and colleagues (152) have shown that the •NO–myoglobin complex is incapable of catalyzing H2O2-dependent LPO,

Wiley also publishes its books in a variety of electronic formats. Some content that appears in print may not be available in electronic formats. For more information about Wiley products, visit our web site at www.wiley.com. Library of Congress Cataloging-in-Publication Data: Grune, Tilman. Protein oxidation and aging / by Tilman Grune, Betul Catalgol, Tobias Jung. p. ; cm. – (Wiley series on protein and peptide science) Includes bibliographical references and index. ISBN 978-0-470-87828-6

change of biomarkers with age. As the oxidative markers are not always measured in the same organs and different methods are used by the different laboratories, it is not surprising that the results are often contradictory. A detailed overview over several oxidative amino acid modifications, specific methods to detect them, and their impact on cell metabolism is given in the reviews from Requena et al. (1108) and Stadtman and Levine (825). The hydroxyl radical converts L-phenylalanine into

scavenger receptors. Biochim. Biophys. Acta 1268: 9–19. Olsson, M. & Oldenborg, P. A. (2008) CD47 on experimentally senescent murine RBCs inhibits phagocytosis following Fcgamma receptor-mediated but not scavenger receptor-mediated recognition by macrophages. Blood 112: 4259– 4267. Tanaka, K., Usui, Y. & Kojo, S. (2001) Role of serum components in the binding and phagocytosis of oxidatively damaged erythrocytes by autologous mouse macrophages. Cell. Mol. Life Sci. 58: 1727–1733. Arese, P.,

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