Epigenetic Shaping of Sociosexual Interactions: From Plants to Humans (Advances in Genetics)
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Epigenetic Shaping of Sociosexual Interactions: From Plants to Humans is the first attempt to interpret the higher social functions of organisms. This volume covers an extraordinarily wide range of biological research and provides a novel framework for understanding human-specific brain functions.
- Covers an extraordinarily wide range of biological research
- Provides a novel framework for understanding human-specific brain functions.
infection in males leads to alterations in DNA methylation that affect genes involved in sex differentiation and development. In another example, Wolbachia density was shown to affect sex ratio in Drosophila innubila by inducing male killing (Dyer, Minhas, & Jaenike, 2005). Bacterial density was found to be an epigenetic and heritable trait, whereby at higher Wolbachia densities females had a more female-biased offspring sex ratio. It was proposed that Wolbachia might interfere with steroid
neuropsychiatric illness. Accordingly, we are only beginning to understand how early experiences influence key biological systems—genetic, neural, endocrine, and immunological—over the long term to produce social gradients in life course trajectories of health and human development. Acknowledgments I would like to thank Dr Shelley E. Brown for her helpful comments and numerous constructive suggestions throughout the preparation of this manuscript. COMPETING INTERESTS STATEMENT The author
directed by the DiGeorge syndrome critical region 8 (DGCR8) protein (Denli, Tops, Plasterk, Ketting, & Hannon, 2004; Gregory et al., 2004). In the cytoplasm, primary miRNAs are recognized and processed by the RNase III Dicer, which generates mature miRNAs. miRNA biogenesis can be modulated by several RNA-binding proteins including Dicer, transactivation response RNA-binding protein, and Ago proteins of the RISC (Figure 2.1). Thus, understanding miRNA functioning will be important for elucidating
gendered behavior. These considerations lead to the important conceptual framework that the sex differences in single cells underlie most gender differences in behavior. This view rationalizes a specific approach for studying the neural basis of gendered behavior. It advocates that the developmental mechanism for single neuron sex differences should be the primary target of study. Figure 3.3 Sexual dimorphism in fru-expressing neurons. (A) mAL as an example of fru-expressing neurons that require
developmental programs for the three sexually dimorphic characteristics of mAL neurons by FruM proteins. 6. Chromatin Modification as a Plausible Mechanistic Basis for the Actions of FruM How is every sexually dimorphic trait regulated in coordination with the other traits of an mAL neuron? Mechanistic insights into the coordinated regulation of three sexual characteristics by FruM have been obtained by the isolation and analysis of a fru genetic modifier, bonus (bon), a null mutant allele of