Epigenetic Shaping of Sociosexual Interactions: From Plants to Humans (Advances in Genetics)
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Epigenetic Shaping of Sociosexual Interactions: From Plants to Humans is the first attempt to interpret the higher social functions of organisms. This volume covers an extraordinarily wide range of biological research and provides a novel framework for understanding human-specific brain functions.
- Covers an extraordinarily wide range of biological research
- Provides a novel framework for understanding human-specific brain functions.
2009). Recently, the same group reported that H3K9me2 is also increased in the parietal cortex of schizophrenia patients and the expression of histone methyl transferase enzymes GLP1 and SETDB1 are upregulated in the same brain region (Chase, Gavin, Guidotti, & Sharma, 2013). In addition, the first study into the three dimensional structure of DNA in postmortem brain samples has been conducted using the chromosome conformation capture (3C) technique (Mitchell et al., 2013). The importance of
acclimatization. Proceedings of the Royal Society. Series B. 2008;275:1359–1365. Kambris Z, Blagborough A.M, Pinto S.B, Blagrove M.S.C, Godfray H.C.J, Sinden R.E, et al. Wolbachia stimulates immune gene expression and inhibits plasmodium development in Anopheles gambiae. PLoS Pathogens. 2010;6:e1001143. Kambris Z, Cook P.E, Phuc H.K, Sinkins S.P. Immune activation by life-shortening Wolbachia and reduced filarial competence in mosquitoes. Science. 2009;326:134–136.
and associated environmental stress. Women exposed to famine in late pregnancy gave birth to smaller babies (Lumey & Stein, 1997) who had an increased risk of insulin resistance later in life (Painter, Roseboom, & Bleker, 2005). Following the famine, offspring who were starved prenatally were found to have impaired glucose tolerance in adulthood when food was more abundant (Stanner et al., 1997). Famine exposure at different stages of gestation was associated with an increased risk of obesity,
fru and dsx for sexual differentiation. Figure 3.4 The mechanism of action of FruM on sexual development of single neurons and fly behavior. Figure 3.5 Hypotheses for the molecular mechanism of action of Fru as an all-or-none sexual switch in neurons. (A) The two-step fru transcription model. (B) The nuclear compartmentalization model for Fru-mediated transcriptional regulation. Figure 4.1 Model of the fly brain illustrating the position and anatomy of the mushroom bodies. Olfactory
LINE-1 copy number. Cytoplasmic inclusions containing the TAR DNA-binding protein 43 (TDP-43) are a defining feature of many neurodegenerative disorders such as amyotrophic lateral sclerosis, frontotemporal lobar degeneration (FTLD), and Alzheimer’s disease (Cohen, Lee, & Trojanowski, 2011). A meta-analysis of published sequencing data from the studies of TDP-43 RNA interaction in the mammalian brain revealed a striking abundance of transcripts from all classes of transposable elements (Li, Jin,