Bioactive Compounds from Marine Extremophiles (SpringerBriefs in Microbiology)
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This SpringerBrief sheds new light on bioactive materials from marine extremophiles. It deals with all aspects of the chemical compounds produced by organisms living under extreme conditions that may have potential as drugs or lead to novel drugs for human use.
O AA 5 N O NH H HO H H H N O 99. Loloatin A OH O O HN O AA 6 N NH2 O O HO HN H N O O NH HN H O O H H AA 6 H N O 100. Loloatin B H OH H NH2 NH2 O H N O AA 10 H HN H N H H HN H O 101. Loloatin C H O OH H AA 5 N NH2 O O H NH H HN NH H AA 6 H N O 102. Loloatin D H O NH H OH O O HO H O O H HN AA 6 H H N H N H H O HN O HN H HN NH HN OH O O NH HO AA 10 H AA 5 N NH2 O O H N O H H O HN O HN O O H O NH2 NH2 O O O
et al. 2001). Compound 107 inhibited electron transport in complex III of the respiratory chain (IC50, 2.5 nM) and exhibited cytotoxic activity against murine leukemia P-388 cells (IC50, 210 nM). Compound 107 also exhibited antimicrobial activity against A. niger (AJ 117374), A. fumigatus (AJ 117190), Botrytis cinerea (AJ 117140), Fusarium sp. (AJ 117167), Mucor hiemalis (AJ 117396), Pythium ultimum (IFO 32210), and Saprolegnia parasitica (IFO 8978) with MIC values of 12.5, 6.3, 3.1, 6.3, 12.5,
C-1027 chromophore-V 244 also inhibited Candida albicans isocitrate lyase, an enzyme that plays a role in the pathogenicity of C. albicans, with IC50 values of 30.4 and 37.9 µM, respectively. These molecules may be intermediates produced by the same biosynthetic pathway; however, they further demonstrate the potential of a single deep-sea microorganism to produce structurally complex molecules with unique chemical features and speciﬁc bioactivity. 3.3 Selective Enzyme Inhibitors Based on the
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