Bioactive Compounds from Marine Extremophiles (SpringerBriefs in Microbiology)

Bioactive Compounds from Marine Extremophiles (SpringerBriefs in Microbiology)

Language: English

Pages: 150

ISBN: 3319143603

Format: PDF / Kindle (mobi) / ePub

​This SpringerBrief sheds new light on bioactive materials from marine extremophiles. It deals with all aspects of the chemical compounds produced by organisms living under extreme conditions that may have potential as drugs or lead to novel drugs for human use.

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O AA 5 N O NH H HO H H H N O 99. Loloatin A OH O O HN O AA 6 N NH2 O O HO HN H N O O NH HN H O O H H AA 6 H N O 100. Loloatin B H OH H NH2 NH2 O H N O AA 10 H HN H N H H HN H O 101. Loloatin C H O OH H AA 5 N NH2 O O H NH H HN NH H AA 6 H N O 102. Loloatin D H O NH H OH O O HO H O O H HN AA 6 H H N H N H H O HN O HN H HN NH HN OH O O NH HO AA 10 H AA 5 N NH2 O O H N O H H O HN O HN O O H O NH2 NH2 O O O

et al. 2001). Compound 107 inhibited electron transport in complex III of the respiratory chain (IC50, 2.5 nM) and exhibited cytotoxic activity against murine leukemia P-388 cells (IC50, 210 nM). Compound 107 also exhibited antimicrobial activity against A. niger (AJ 117374), A. fumigatus (AJ 117190), Botrytis cinerea (AJ 117140), Fusarium sp. (AJ 117167), Mucor hiemalis (AJ 117396), Pythium ultimum (IFO 32210), and Saprolegnia parasitica (IFO 8978) with MIC values of 12.5, 6.3, 3.1, 6.3, 12.5,

C-1027 chromophore-V 244 also inhibited Candida albicans isocitrate lyase, an enzyme that plays a role in the pathogenicity of C. albicans, with IC50 values of 30.4 and 37.9 µM, respectively. These molecules may be intermediates produced by the same biosynthetic pathway; however, they further demonstrate the potential of a single deep-sea microorganism to produce structurally complex molecules with unique chemical features and specific bioactivity. 3.3 Selective Enzyme Inhibitors Based on the

Environ Microbiol 68:3628–3633 Haigh WG (1994) High purity beta-carotene. USA Patent Hale KJ, Dimopoulos P, Cheung MLF, Frigerio M, Steed JW, Levett PC (2002) A biosynthetic proposal for ring formation in the antitumor agent halichomycin. Asymmetric synthesis of the AB-carbon backbone of halichomycin. Org Lett 4:897–900 Hamann MT, Otto CS, Scheuer PJ, Dunbar DC (1996) Kahalalides: bioactive peptides from a marine mollusk Elysia rufescens and its algal diet Bryopsis sp. J Org Chem 61:6594–6600

Avron M (1991) Production and selection of high β-carotene mutants of Dunaliella bardawil (chlorophyta). J Phycol 27:652–656 Sheih IC, Wu T-K, Fang TJ (2009) Antioxidant properties of a new antioxidative peptide from algae protein waste hydrolysate in different oxidation systems. Bioresour Technol 100:3419–3425 Shigemori H, Bae MA, Yazawa K, Sasaki T, Kobayashi J (1992) Alteramide A, a new tetracyclic alkaloid from a bacterium Alteromonas sp. associated with the marine sponge Halichondria okadai.

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